1、南京理工大學(xué)碩士學(xué)位論文非剛性醫(yī)學(xué)圖像配準(zhǔn)方法的研究與實(shí)現(xiàn)姓名：陳國(guó)琳申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：計(jì)算機(jī)應(yīng)用技術(shù)指導(dǎo)教師：湯楊20090621碩士論文非剛性醫(yī)學(xué)圖像配準(zhǔn)方法的研究‘j實(shí)現(xiàn)AbstractMedicalimageregistrationswhichcallmappoints(orsurface)fromonemedicalimagetohomologouspointsonanobjectinthesecondimageison

2、eofthefundamentaltasksinimageprocessing，andthenfusethemintoanewimagetoprovidedoctorsmorerichclinicalinformation，makingallkindsofvideoequipmentintheinformationcomplementaryadvantageDuetothediversityandcomplexityofthemedic

3、alimage，whichmethodofimageregistrationCanbechoseandappliedisdependontheproblemProperregistrationmethodshavetobeselectedtoaimatspecificsubjectsinvestigatedandconsideredtocomplementeachotherintermsofmaximizingfavorablefact

4、orsandminimizingunfavorableonesBasedonmanyimportantclinicalapplicationsneedtodescribethespatialoftheimageusingthenonrigidtransformation，thisthesisresearchesonsomemethodsofnonrigidregistrationandimprovesthem，thenanalysesb

5、oththeprecisionandefficiencyofregistrationTheconcretestudiesareasfollows：Firstly，non—rigidregistrationbasedonpixelshasbeenresearchedintheaspectofregistrationprecisionUndertheframeworkofdifferential，byusingthemodeloflocal

6、affinetransformationandglobalsmoothingconstraint，itcapturesthenonlineardistortions，simulatingtheelastictransformationofthemedicalimageThesimulationexperimentshowsthatthealgorithmispracticalandtheresultsareanalyzed，highli

7、ghtingtheproblemoflowefficiencyofregistrationSecondly，accordingtotimeconsuming，themodeloffreeformdeformation(FFD)basedonBsplinehasbeenstudiedBasedonlayeredandmultiresolution，normalizedmutualinformationhasbeenadoptedassim

8、ilaritymeasureAtthesametime，imageblockingwhichisfeaturedwithrapidcalculationoflocalupdatinghasbeenusedtosimulatelocalelasticdeformationtoincreasetheefficiencyoftheregistrationThesimulationexperimentsshowthatthealgorithmi

9、spractical，andevaluationparameters，suchassumofsqureddifference，correlationcoefficientandtime，havebeenusedtocomparewiththealgorithmstudiedaboveFinally，Basedonthealgorithmsstudiedabove，amethodofnon—rigidregistrationwhichco

10、mbinedB—splinewithpixelisformedtoincreasetheprecisionofregistration，besides，itinheritstheiradvantagesSoithasuniversalsignificanceAccordingtoexisttheproblemoflowefficiency，akindofHermitederivativefilterisintroducedintothe