1、湘潭大學碩士學位論文煙酸衍生智能高分子的合成及其在藥物控制釋放中的應用姓名：陳小萍申請學位級別：碩士專業(yè)：高分子化學與物理指導教師：蔡遠利20080522VAbstractPolymericprodrugsarepolymersthatdrugsarecovalentlyboundtopolymers.Becauseoflowtoxicityhighefficiencycontrolleddrugreleasetheybecomemem

2、eimptantinbiomedicalfield.InrecentyearspHresponsivepolymershavebeenextensivelyinvestigated.Asaparticulartypeofsmartmaterialstheyexhibitedextensivelypotentialapplications.ClearlydevelopinganewtypeofpHresponsivepolymericpr

3、odrugisdesirablefromacademicindustrialstpoints.Inthispaperanicotinicacidbasedmonomermethacryloyloxylethyl3pyridylfmate(MAEPF)wassynthesizedacterized.ArangeofwelldefinedPMAEPFpolymersweresynthesizedviahighlyefficientwellc

4、ontrolled2cyanoprop2yl(4fluo)dithiobenzoateCPFDBmediatedRAFTpolymerizationofMAEPFmonomerunderanenvironmentallyfriendlyvisiblelightradiationat30oCusing(246trimethylbenzoyl)diphenylphosphineoxide(TPO)asaphotoinitiat.Kiicst

5、udiesindicatedthatthisRAFTpolymerizationwaswellcontrolled.Arelativelylowconcentrationofchaintransferagent(CTA)ledtobotheffectsofshteninginitializationperiodofthisRAFTprocessacceleratingtheoverallpolymerizationrate.Meover

6、avarietyofwelldefinedPMAEPFbasedblockcopolymerswithpoly[poly(ethyleneglycol)monomethacrylate](PPEGMA)blockspoly(NNdimethylaminoethylmethacrylate)(PDMAEMA)blockspoly(glycidylmethacrylate)(PGMA)blocksweresynthesizedviaambi

7、enttemperatureRAFTpolymerizationunderthismildvisiblelightradiationat30oCusingabovesynthesizedPMAEPFpolymersasmacroCTA.TheeffectofmolecularweightsofPMAEPFdipyridamolecontents(DIP)ontheglasstransitiontemperature(Tg)ofthese

8、polymersblendswereinvestigated.TheresultsindicatedthatTgofPMAEPFpolymerswerearound50oC.OnadditionofDIPtheglasstransitiontemperatureoftheirblendswasdramaticallyloweredtoaroundroomtemperature.Themolecularweightstructuralun

9、itratioofPMAEPFtoPPEGMAsignificantlyaffectedthemicellizationofPMAEPFbPPEGMAcopolymerinaqueoussolution.ThesolutionpHhadnegligibleinfluenceonthePMAEPFbPPEGMAcopolymermicellesduetotheglassstateofPMAEPFmicellarcesatambientte