1、蘭州大學碩士學位論文腦紅蛋白在阻塞性睡眠呼吸暫停低通氣綜合征和急性腦梗死患者的表達及相關性研究姓名：王法紅申請學位級別：碩士專業(yè)：內(nèi)科學（呼吸病學）指導教師：岳紅梅20100601蘭州大學碩士學位論文Expressionofserumneuroglobinandcorrelationbetweenobstructivesleepapnea—hypopneasyndromeandacutecerebralinfarctionAbstrac

2、tObjective：Toexplorethecorrelationbetweentheregularityofneuroglobinexpressionandearlybraininju拶becauseofthechronicintermittenthypoxiainpatientswithobstructivesleepapneahypopneasyndrome(OSAHS)andacutecerebralinfarctionMet

3、hods：Afterthcywereevaluatedbyfullnightpolysomnography40patientswithOSAHS，16acutecerebralinfarctionsubjectsand16nornalcontrolswereresearched髂theobjectsFirstOSAHSandnomalcontrols’venousbloodwerecollectedatthesecondmoringan

4、dacutecerebralinfarctionsubjects“werecollectedatthe48thhouroftheictusSecond，theywerecoldstoragedinarefrigeratorof一80℃L戤Serumlevelsofneuroglobinweredetectedbyenzyme—linkedimmunosorbentassaymethodResults：Serumlevelsofneuro

5、globininOSAHSgroup(1085O)Itg／Landacutecerebralinfarctiongroup(116a：36)燼幾areremarkablyhigherthanthatcontrolgroup(3釷14)“g／L(bothP005)TheconcentrationofserunlneuroglobininpatientswithOSAHSarepositivelycorrelatedwithapneahyp

6、opneaindex(岡948，PO05)Conclusion：1BecauseserumlevelsofneuroglobininOSAHSgroupandACIgroupwereremarkablyhigh，weconfirmtobraininjuryoccursinpatientswithOSAHSandacutehypoxiaorchronicintermittenthypoxiamayinducethebraininjurya