1、分類號：N94密級：公開UDC：004學校代碼：11065碩士學位論文基于復雜網(wǎng)絡的人類視網(wǎng)膜色素變性的位點基因型相互作用網(wǎng)絡構建及相關性分析基于復雜網(wǎng)絡的人類視網(wǎng)膜色素變性的位點基因型相互作用網(wǎng)絡構建及相關性分析胡建龍指導教師邵峰晶教授學科專業(yè)名稱計算機科學與技術論文答辯日期2015年6月5日AbstractTheanalysisofpathogenesisofgeicdiseasesoftenrequireslargeexpensi

2、vebiologicalexperimentslongtimeexperienceaccumulationoftheclinicaldiagnosisofgeicdisease.Thebiologicaldatawasveryhugecomplex.Therefethispaperusedataminingtechnologycomplexwktheytodesignthediscoverymethodofpathogenesisofg

3、eicdiseaseswhichmakesthediscoveryprocessautomationshtensthediscoverytimereducesexpenseshavesomereferencevaluetopredictdiagnosetheillnessinthemolecularlevel.Therefebasedonhumanretinitispigmentosacasescontroldatasetthispap

4、erusedataminingtechnologycomplexwktheytofindthepathogenicmechanismofhumanretinitispigmentosa.Themainresearcheswksofthispaperareasfollow:(1)highefficiencyminingalgithmfassociationrulesbetweenphenotypeslocus.Thispaperpropo

5、sedmatchtofindabiologystatisticalsignificanceassociationruleswithlowsupptusedparallelcomputingtospeedupassociationrulesalgithm.(2)Toconstructtheinteractionwkbetweenlocigenotypes.Thispaperuseassociationrulealgithmstofindt

6、heinteractionbetweenlocigenotypes.Thispaperconstructlocigenotypesinteractionwkwithlocigenotypesasnodesinteractionoflocigenotypesasedges.wkofcasescontrolswereconstructedthenthispapercompareanalyzethestatisticaldiscrepancy

7、ftheproptiontopologicalpropertiesofnodesbetweenthetwowks.(3)TorevealpathogenicmechanismofhumanretinitispigmentosabasedonLocigenotypesinteractionwk.Thispaperfind3nodemotifsincasescontrolslocusinteractionwkrespectivelythen