1、浙江大學(xué)碩士學(xué)位論文Synthesisoft—lactamDerivativesviaIntramolecularEneReactionandnrylInvolvedIntramolecularDielsAlderReaction⑧ByJianZhanglanLhanRSupervisedbyProfJinlongWuInstituteofOrganicChemistryDepartmentofChemistryZhejiangUniv

2、ersityHangzhou，RRCMay2014’浙江大學(xué)碩士學(xué)位論文AbstractIntramolecularenereactionandintramolecularDiels‘Aldercycloadditionaretwokindsofimportantreactionsforefficientlyformingcarboncarbonbondsinorganicsynthesis，theyareeffectivemeanst

3、obuildringstructuresnetopicofthisthesisisthesynthesisofy—lactamderivativesviaintramolecularenereactionandarylinvolvedintramolecularDielsAlderreactionsInthefirstchapterofthisthesis，themechanismofenereactionandDiels—Alderr

4、eactionweredescribedbrieflyTheaffectingfactorsofthephenylinvolvedintramolecularDielsAlderreactionaLswellaStheimpactofactivatinggroupandthestereoselectivityoftheintramolecularenereactionwerediscussedalsoBesides，thereWaSab

5、riefintroductiontothephenylinvolvedintramolecularDielsAlderreactionsandintramoleculareriereactionsinorganicsynthesisapplicationsInthesecondchapterofthisthesistheresearchpurposethatsynthesisofsubstrateswithdifferentstruct

6、urestostudytheinrtramolecularenereactionandphenylinvolvedintramolecularDielsAlderreactionofthemandtosynthesizehighlysubstituted71actamderivativeswhichcontaincomplexstructuresatthesametimeWaSdescribedBasedonthisresearchpu

7、rpose，avarietyofamidetethered16dienesubstratesweresynthesizedthroughareaSonablydesignedsyntheticrouteInacetonilrile，heatedinsealedvial，amidetethered1methylor7methyl一1，6一dienesubstrates(237a—d，240bc)occuredtheintramolecul

8、arenereaction，amidetethered1，7dimethyl1，6一dienesubstrate(240a)reactedregioselectivelytoaffordintramolecularenereactionproducts，affectedbytheactivatedgroupat7carbon；howeveramidetethered1phenyl7methyl一1，6一dienesubstrates，w

9、henthebenzeneringwithweakelectronwithdrawingorelectrondonatinggroups(237e—h)，enereactionoccuredonlybutwhenconnectedastrongelectronwithdrawinggroup，nitrogroup(244)，themainproductWaSaffordedviabenzeneringinvolvedintramolec