1、東北農(nóng)業(yè)大學碩士學位論文鹽酸沙拉沙星在蛋雞體內(nèi)的組織動力學及殘留的研究姓名：李艷華申請學位級別：碩士專業(yè)：獸醫(yī)藥學理學與毒理學指導(dǎo)教師：佟恒敏2000.5.1碩士學位論文英文摘要東北農(nóng)大動物醫(yī)學院StudiesontissuePharmacokineticsandtheResiduesofSarafloxacinHydrochlorideinchickenABSTRACTSaratloxacinHydrochlorideisoneoff

2、loroquinolonesonlYusedforanimalsinfectiousdiseasesInthisthesis，thepharmacokineticsprocessofsarafloxacinHydrochlorideofchickenandtheresidueintissueofchickenarestudiedbyusingthem曲performanceliquidchromatographyHPLC、procedu

3、re111edynamicinterrelatedrelationshipofthedruglevelbetweensePdmandtissuewereanalyzedbytheuseoftheregressionanalysis，andtheindirectlypredictiveequationaboutthedrugconcentrationintissueisestablishedThedatawereanalyzedwitht

4、hePharmacolineticscomputerprogramMCPKPPharmacolineticsshowthatthebloodconcentrationtimecoursecallbedescribedwiththefirstcompartmentopenmodelwiththefirstorderabsorotionafteroraladministration(10mg／kg)Itstheoreticalequatio

5、nwasasfollows：Ch21036(e4‘eZ057t)，itsmainpharmacokineticsparameterstlnk3793hrS、‰15807hrS、crrⅢo7429“g／ml、AUC53790ug／m1h。ThekineticsprocessSarafloxacinHydrochloddeintissues：theheartconcentrationtime(C，DdataofSarafloxacinHyd

6、rochlorideWasbestdescribedbyatriexponentialequationwi廿1firstorderabsorptionItstheoreticalequationwasasfollows：C。=01455e“㈣2484e‘”“3L2629e?！薄?，itsmainpharmacokineticsparameterstl艫765hrs、tlml6027hrs、tml6826hrs、c。x0、5129ug／ml

7、、AuC90265pg／m1haTheheartconcenWaiontime(C一T3dataofSarafloxacinHydrochlorideWaSbestdescribedbyatriexponentialequationwithfirstorderabsorptionItstheoreticalequationwasasfollows：Ck=1703e4112‰3283e02111t20312e44“，itsmainphar

8、macokineticsparameterstl∞4026hrs、t小418hrs、‰19855hrs、c。09090ug／ml、AUCl0894ug／m1h111eliverconcentrationtime(CiDdataofSamtloxacinHydrochlorideWasbestdescribedbyabiexponentialequationwithfirstorderabsorptionItstheoreticalequ

9、ationWasasfollows：CI=6732釅”‘eO1i“)，itsmainpharmacokineticsparametersttak31587llrS、k般19764hrs、c雕3737“g／ml、AUC31354“g／m1hThemuscleconcentrationtime(CrtldataofSarafioxacinHydrocllofideWasbestdescribedbyabiexponentialequatio

10、nwithfirstordel“absorotionItstheoreticalequationwasasfollows：Cm=09188(eoJ579te02014t)itsmainpharmacokineticsparameterstlm4124hrs、k眥35679hrs、c?！皁6956“g／ml、Auc53269g／m1hrsTissuepharmacokineticsindicatesSarafloxacinHydrochl