1、青島大學(xué)碩士學(xué)位論文氨基末端前體腦鈉肽與左室舒張功能的相關(guān)性研究姓名：郭潔申請學(xué)位級別：碩士專業(yè)：心血管內(nèi)科學(xué)指導(dǎo)教師：沃金善20080601AbstractAIM：ToinvestigatetherelationshipbetweenNterminalprobrainnatriureticpeptide(NT—proBNP)andleftventriculardiastolicfunctionMETHODS：①Fiftythreepa

2、tientswithisolateddiastolicdysfunctionandpreservedleftventricularejectionfractionandthirtyfourpatientswithregularleftventricularfunctionasnormalcontrolwereexaminedbyconventionalechocardiography，tissueDopplerimaging，andle

3、ftheartcatheterization②趟lthesubjectswerestudiedv／aelectrochemicalradiationtotestNT—proBNPlevels；Echocardiogram，tissueDopplerimagingandleftheartcatheterizationwereappliedtodetecttheparameterstoreflectleftventriculardiasto

4、licfunction；thecorrelationofNTproBNPlevelsandthediastolicfunctionparameterswasalsoanalyzedRESULTS：①NTproBNPplasmalevelswereelevated【106401458985pg／ml(22324569pg／m1)VS617944576pg／ml(684—1322pg／m1)；P0001】andincreasedwithgr

5、eaterseverityofthediastolicdysfunction(R=O71，P0001)②Leftventricularend—diastolicpressure(areaunderthecurve(AUC)082)wasthemostspecificparameterwhichhadalowsensitivity(73％)，howeverThereliabilityofNTproBNPWassimilartotissue

6、Dopplerimagingindices(AUC076vs077)andimprovedwhencomparedwithconventionalechocardiography(AUC060—075)NTproBNPlevelshadthebestnegativepredictivevalueofallmethods(93％)andcorrelatedstronglywithindicesofleftventricularend—di

7、astolicpressure(R=048，P0001)，asdeterminedbyinvasivemeasurementsMultivariablelinearregressionanalysisconfirmedNTproBNPasanindependentpredictorofdiastolicdysfunctionwithanOddsratioof1237(1019—1427，CI95％)CONCLUSIO：NT—proBNP

8、canreliablydetectthepresenceofisolateddiastolicdysfunctioninsymptomaticpatientsPostgraduatestudent：GuoJie(Cardiology)DirectedbyAssociateprofWoJinshanKEYWORDS：Leftventricularfunction；Diastolicfunction；Nterminalpro—B毋penat