1、同濟大學(xué)理學(xué)院碩士學(xué)位論文可注射性納米骨修復(fù)材料的研究姓名：楊四川申請學(xué)位級別：碩士專業(yè)：環(huán)境科學(xué)指導(dǎo)教師：孫曉宇汪世龍20060101AbstractAbstractHydroxyapatitehasthesimilarstructure、析ththeinorganiccomponentofhumanboneswhichleadstoitsgoodbiologycompatibility，boneconductivityandindu

2、ctivitySoit’Softenreportedtobeused硒bonerestoringmaterialsButhydroxyaptitehaslowmechanicalpropertiesandit’Shardtobemolded，whichhandicapsitsdevelopmentalotNowit’Sapromisingwaytouseothermaterialstoimprovethemechanicalproper

3、tiesofhydroxyapatite，andtherehavebeenmanyachievementsreportedButtherehavebeenfewresearchesreportedaboutusingmedicalcalciumsulfatetoimprovethemechanicalpropertiesofnanometerhydroxyapmiteanddoingresearchaboutitsrestoration

4、effectsinthighbonedefectofrabbitsAndthat’SwhatmyexperimentsallaboutInmyexperiment，nanometerhydroxyapatiteissynthesizedwhichhasthesimilarshapesandsizewitllthehydroxyapatiteinhumanbonesThenitismodifiedwithmedicalcalciumsul

5、fate，andprepareaninjectablenanometerscalebonesubstitute，whosehardeningtimeandcompressivestrengtharestudiedFurthermore，itissoakedinthesimulatedbodyfluid(SBF)tostudyitsabsorptiontolearnsomethingaboutitsabsorptioninhumanbod

6、ybyanalogyAfterprovingitisharmlessforcellsthroughcelluartoxicityexperimentMTT，it’Sfinallyusedtocurethethighbonesdefectofrabbits’AndtheeffectisbeenassessedbyXrays，histologyobservationandelectricalmicroscopeevery2weeksConc

7、lusions：(1)Thesynthesizednanoscalehydroxyapatitecrystalsislikerod，whichhasabout65nmlengthand1020nmwidth(2)ThecompressivestrengthofthemulriplematerialisbetweenthatofspongybonesandOSintegumentalesofhumanbody(3)ItreleasesCa

8、lciumandPhosphoruscontinuallywhensoakedinSBF，whichsuppliesalotofCalciumandPhosphorustohelpbonegrowthAndithaslargervelocitythanpureCalciumsulfatematerialandpurehydroxyapatite(4)Itscelluartoxicitygradeis0or1grade，anditWOn’

9、tresultindropsy，fester，fibresandputrescenceinrabbits’muscles，whichprovesitsgoodbiologicalcompatibility(5)6weeksafterthesurgery，thethighbonedefectsusingthematerialhasbeencuredwhilethosewhichdidn’tuseitjusthadobviousbonegr