1、南昌大學醫(yī)學院碩士學位論文結直腸癌中AQP5、ERK蛋白表達及其相關性研究姓名：聶鴻申請學位級別：碩士專業(yè)：病理學與病理生理學指導教師：路名芝20090610AbstractABSTRACTobjective：Toinvestigatetheexpressionofaquaporin5(AQP5)andextracellularsignalregulatedkinaseprotein(ERK)andtheircorrelationinc

2、olorectalcarcinomaMethods：ThedifferentialproteinexpressionofAQP5andERKbetween60samplesofcolorectalcarcinomaand20samplesofitscorrespondingnormalcolorectalmucosawasanalyzedbymicrotissuearrayandimmunohistochemistryMoreoverT

3、heAQP5andERKproteinexpressionwerefurtheranalyzedbyWesternblottinghybridizationin15colorectalcarcinomatissueversusthecounterpartsResults：(DTheexpressionofAQP5andERKproteinincolorectalcareinomabyin衛(wèi)nunohistochemistrywashig

4、herthaninthecorrespondingnormalcolorectalmucosaBothexpressionofAQP5andERKproteinwererelatedwiththedepthoftumorinvasion，lymphnodemetastasisandTNMstage(P005)②TheresultsofWesternblottingsuggestedthatof15pairedsamples，AQP5an

5、dERKproteinWasupregulatedineolorectalcarcinomacomparedwiththeirnormalcolorctalmucosainallthecases(P005)FurthersemiquantitiveproteinexpressionofAQP5andERKwerealselatedwiththedepthoftumorinvasion，lymphnodemetastasisandTNMs

6、tage(P005)MoreovertheexpressionofAQP5proteinWaspositivelyrelatedWiththeexpressionofERKproeinincolorectalcarcinoma(PO05)Conclusions：ThesefindingsindicatethatexpressionlevelofAQP5andERKproteiniscloselyrelatedtothebiologica

7、lbehaviorofcolorectalcancelTheexpressionlevelofAQP5proteiniscloselyassociatedwiththeoverexpressionofERKproteinAQP5proteinmaybeabletopromoteRas／Raf／MEK／ERKsignalingpathways，resultingininvasionandmetastasisKeyWords：colorec