1、分類號：R69 密級：不保密UDC： UDC： 610 學(xué)校代碼： 11065碩士學(xué)位論文Tim-3在膀胱尿路上皮癌中的表達(dá)及其臨床意義 Tim-3在膀胱尿路上皮癌中的表達(dá)及其臨床意義楊 猛指 導(dǎo) 教 師 于 芹 超學(xué) 科 專 業(yè) 名 稱 外科學(xué) （泌尿外科）論 文 答 辯 日 期 2015 年 5 月 31 日The clinical significance of Tim-3 expression in bladder urothe

2、lialcarcinomaAbstractObjective: To investigate the clinicalcopathologic correlations and survivalassociation between the expression of Tim-3 and bladder urothelial carcinoma (BUC).Methodology: We detected Tim-3 expressio

3、n in 100 human BUC tissues and 20normal bladder mucous tissue specimens by immunohistochemistry (IHC). And thecorrelations between Tim-3 expression levels and prognosis were also evaluatedaccording to clinical features.R

4、esults: High Tim-3 positive expression was detected from 95 out of 100 (95 %)tissue specimens of patients with BUC. Patients who suffer high grade and advancedstage presented high Tim-3 expression. The expression of Tim-

5、3 has significantlyassociated with tumor grade (P = 0.001) and stage (P = 0.004). Univarite (P = 0.003)and multivariate (P = 0.039, RR = 4.775) analysis have been shown that Tim-3expression was an important prognostic fa

6、ctor associated with shorter overall survival.Conclusion: High Tim-3 expression was verified in BUC tissues, which play an vitalrole in promote the progression of BUC. Our study suggested that the over-expressionof Tim-3

7、 in bladder tumor tissues may be an independent prognostic factor in BUCpatients.Postgraduate student: Meng Yang (Urology)Directed by Prof.: Qinchao YuKey words：Tim-3; Bladder urothelial carcinoma (BUC); Survival analysi