1、大連醫(yī)科大學碩士學位論文抑癌基因nm23對胃癌淋巴轉(zhuǎn)移作用的研究姓名：馬曉波申請學位級別：碩士專業(yè)：外科學指導教師：馮秉安20050601StudyOntheEffectofAnti—oncogenenm23toLymphaticMetastasisofGastricCancerPostgraduate：MaXiaoboSupervisor：FengBing—anMajor：SurgeryAbstractobjectiveTostudy

2、thevascularendothelialgrowthfactorC(VEGF—C)relatedmechanismoflymphaticmetastasisinhumangastriccancerandtoexploretheeffectofantioncogenenm23expressiononlymphaticmetastasisofgastriccancelMel：hodsImmunohistochemcalmethodwas

3、usedtodetecttheexpressionofnm23、VEGFCandVEGFR3in68humangastriccancertissues：thepositiverateofnm23、VEGF—Candlymphaticmicrovesseldensity(LMVD)werecaculated：Correlationanalysiswascarryoutamonglymphaticmetastasis、LMVDandthee

4、xpressionofnm23andVEGFCResultsVEGF—CpositiverateandLMVDoflymphnodespositivespecimenweresignificantlyhigherthanthoseoflymphnodesnegativespecimen(7005％／3000％，p005：3160／2020，p005)；comparedwithVEGF—Cnegativegroup，LMVDofVEGF—

5、Cpositivegroupincreasednotably(2960／2140，p005)Compared、Ⅳimlymphnodesnegativegroup，thepositiverateofnm23H1expressioninlymphnodesmetastasisgroupwassignificantlydecreased(2632％／7000％，p005)Comparedwiththenm23一H1negativegroup

6、，VEGFCexpressionandLMVDinnm23Hlpositivegroupdecreasedsignificantly(3548％／6757％，p005：1961／31，93，p005)CorrelationanalysisshowedthatpositivecorrelationexistedbetweenlymphnodesmetastasisandVEGF—Cexpression、LMVD(B=O878andO。40