1、腹腔鏡輔助結直腸手術的歷史,首例腹腔鏡輔助結腸腸手術于1991年Redine DB完成首例腹腔鏡輔助結腸腸癌手術1991年由Jacobs M完成香港、臺灣、韓國、日本、歐美等國家開展比較普及國內京津環(huán)渤海、珠三角、長三角、成渝較普及,腹腔鏡結直腸癌手術種類,完全腹腔鏡手術腹腔鏡輔助手術手助腹腔鏡手術,laparoscopic resection of rectosigmoid carcinoma:prospective ra

2、ndomised trial,Leung KL, et al. Lancet;2004,363,(9416),1187~1192,,,,,,,北美外科治療臨床療效研究組（COST）,腹腔鏡組428例 開腹組435例中轉開腹21%（90/435）手術時間150min對90min術后恢復腹腔鏡組更快住院時間更短3d對4d手術期間并發(fā)癥術后30日內死亡率術后60天內并發(fā)癥再入院率在

3、手術率,,差異無顯著性,n engl j med 350;20 13, 2004,切口長度,手術時間,口服鎮(zhèn)痛藥,弱安定藥,住院日,,并發(fā)癥,,,,,根治性,Cost,,,Cost研究腫瘤復發(fā)轉移比較,腹腔鏡組16%,開腹組18%,Cost研究3年生存率比較,腹腔鏡組86%,開腹組85%,Cost研究長期隨訪結果,Patients were followed for 8 years, with 5-year data on 90

4、% of patients. median of 7 years (range 5-10 years) .Disease-free 5-year survival (Open 68.4%, Laparoscopic 69.2%, P=0.94) Overall 5-year survival (Open 74.6%, Laparoscopic 76.4%, P=0.93) Overall recurrence rates were

5、 similar for the 2 groups (Open 21.8%, Laparoscopic 19.4%, P=0.25) These recurrences were distributed similarly between the 2 treatment groups (Open: wound 0.5%, liver 5.8%, lung 4.6%, other 8.4%; Laparoscopic: wound 0.

6、9%, liver 5.5%, lung 4.6%, other 6.1%). CONCLUSION: Laparoscopic colectomy for curable colon cancer is not inferior to open surgery based on long-term oncologic endpoints from a prospective randomized trial.,Ann Surg.

7、2007 Oct;246(4):655-62; discussion 662-4,Long-term outcome of laparoscopic surgery for colorectal cancer:A cochrane systematic review of randomised controlled trials.,Results: Twelve trials (3346 patients) reported long

8、-term outcome 腹腔鏡和開放結直腸癌切除在切口疝和因腸粘連再手術方面無顯著性差異 (p = 0.32 and 0.30, respectively)Trocar和切口部位轉移上無顯著性差異(p = 0.16).癌有關的死亡率在最大隨訪期內相似 (p = 0.15 and 0.16 for colon and rectal cancer, respectively)腹腔鏡與開放結腸癌切除術后癌復發(fā)轉移無顯著性差

9、異在隨訪期內腹腔鏡與開放手術術后死亡率無顯著性差異Conclusions: Laparoscopic resection of carcinoma of the colon is associated with a long-term outcome that is similar to that after open colectomy. Laparoscopic surgery for cancer of the upper

10、 rectum is feasible, but more randomised trials need to be conducted to assess long-term outcome.,Cancer Treat Rev (2008), doi:10.1016/j.ctrv.2008.03.011,腹腔鏡結直腸癌手術進展,手術根治性與開腹手術相同標本長度、切緣陽性率及淋巴結檢出數量等;手術安全性好術中并發(fā)癥、術后總體并發(fā)癥