1、y1109606分類號(hào)：密級(jí)：?jiǎn)挝淮a學(xué)號(hào)依達(dá)拉奉對(duì)腦血栓形成大鼠模型的腦保護(hù)作用研究生：一閨主指導(dǎo)教師：苤握題熬援申請(qǐng)學(xué)位門類級(jí)別：專業(yè)名稱：研究方向：所在學(xué)院：亟主擅經(jīng)瘟堂——膻堂蟹疸璁匝出酉醫(yī)抖盔堂簋=監(jiān)鏖醫(yī)生瞳2007年4月20日101142004”5山西醫(yī)科大學(xué)硬士學(xué)位論文CerebralProtectionofEdaravoneOnCerebraIThrombosisRatsAbstractobjectiveEvaluate

2、cerebralprotectionofEdaravonebydetectingtheSCOreofbehavioraldisturbance，thevalueofplasmaPAconcentrationandthebraintissuemoisturecapacityMethodsCerebralthrombosisratsmodelwereproducedthroughinjectingthrombinintotheinterna

3、lcarotidarterybyintroducingacatheter60Wistarratsweredividedinto5groupsrandomly(normalcontrolgroup，shamoperationgroup，cerebralischemiagroup，Edaravone—ischemiagroupandsalineischemiagrouprespectively)，eachhas12ratsObserveth

4、echangesofbehavioraldisturbance，thevalueofplasmaPAconcentrationandbraintissuemoisturecapacityoftheratsineachgroupResultsInthenormalcontrolgroup，theratshadnobehavioraldisturbance，thevalueofPAwas311060Ilmol／Landthebraintis

5、suemoisturecapacitywas7587147(％)Inshamoperationgroup，theratsalsohadnobehavioraldisturbance，thevalueofPAwas34l056umol／LandthebraintissuemoisturecapadtyWas76331160(％)TherewerenosignificantdifferencesbetweenthetwogroupsButi

6、ncerebralischemiagroup，thescoreofbehavioraldisturbanceissignificant(900154)，thevalueofPAwashigher(1051O98IImol／L)，andthebraintissuemoisturecapacityincreased(7633t160(％))thanthenormalcontrolgroupIntheEdaravone—ischemiagro

7、up，thescoreofbehavioraldisturbanceWas633130，thevalueofPAwas592052umol幾andthebraintissuemoisturehpacityWas7937161(％)Inthesaline—ischemiagroup，thescoreofbehavioraldisturbanceWas875122，thevalueofPAwasl086092lZmol／Landthebra

8、intissuemoisturecapacitywas8282229(％)ThereweresignificantdifferencesamongnormalthecontrolgrouptheEdaravoneischemiagroupandthesaline—ischemiagroupItindicatesthatEdaravonecanpartlydecreasetheScoreofbehavioraldisturbance，th

9、evalueofPAandthebraintissuemoisturecapacityConclusionsItindicatesthatexperimentalratsmodelswithcerebralthrombosisinourexperimentweresuccessfulfromthescoreofbehavioraldisturbance，thevalueofPAandthebraintissuemoisturecapac

10、ityByinstillingEdaravoneintothestomachoftheratsbeforethesurgery，thesCOreofbehavioraldisturbance，thevalueofPAandthebraintissuemoisturecapacityweredecreasedWeconcludedthatEdaravoneasaneuroprotectiveagentiseffectiveinthetre